Our Services

The OGI Genomics Core provides researchers and clinicians with comprehensive support for translational and clinical sequencing projects, with a full range of sample processing services designed to ensure high-quality results.

As a CLIA-certified laboratory offering diagnostic testing to MEEI clinicians, we can provide the same quality services to researchers from specimen collection and accessioning through various NGS assays and bioinformatics analysis in collaboration with the MEEI Bioinformatics Center.

The OGI offers sample processing services which include nucleic acid, serum and plasmid isolation, all with barcoded sample storage and management to ensure proper tracking throughout the workflow. Our LIMS allows any additional information to be added along with further assay results such as genotyping, WES or WGS.

The Genomics core provides a wide range of sequencing services including both Sanger sequencing and next generation sequencing (NGS). We offer library preparation for amplicon sequencing, plasmid sequencing, whole exome sequencing, selective exon capture and next generation sequencing (NGS) for ocular disease genes (RetNeT, glaucoma, optic neuropathy, mitochondrial DNA), whole genome sequencing, and both bulk and single-cell RNA sequencing. We can also load your prepared libraries to your specifications on our Illumina Miseq or Novaseq6000. We are happy to assist you with your custom sequencing project, please feel free to contact us for a consultation.

We provide instrumentation for use by investigators after training for nucleic acid analysis and sample preparation. These same services are available by our staff as well. We have a bank of thermocyclers available on a first come first use basis.

Our History

The OGI Genomics Core facility was established in April of 2013 by the Massachusetts Eye and Ear Department of Ophthalmology and with support of an NEI P30 grant (EY014104), with the goal of offering advanced genomics analysis methods and techniques to MEE investigators and affiliates.

Please Read Before Submitting:

• All users must be trained by core staff to use any “self-service” instruments. Please sign up for training before requesting or scheduling these instruments.
• Please read sample submission guidelines carefully to ensure your project gets processed in a timely manner and you receive the best possible results.
• Sample ID must be no longer than 5 characters and not contain any special characters, spaces or dashes, only underscores if necessary. Each sample ID must be unique across all submissions for all samples. Example: HS_001. The sample ID must match the label on the top of the tube.
• We look forward to collaborating! Please email to discuss your project with a member of our core staff if you don’t see it listed here. You can also request a quote; email ogicore@meei.harvard.edu with the following information:

Investigator Name
Phone Number
Email Address
Request Information

*Request Information should include as much detail as possible about your project requirements.

All publications and presentations from work received through the OGI Genomics Core must
include the following in the Acknowledgements or funding sources; NIH National Eye Institute
Core Grant P30EY014104.

If a core member collaborated with the design of your project, please consider adding them as
an author on your manuscript.