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Ocular Genomics Institute researchers find a connection between changes in the extracellular matrix of Bruch’s membrane and the activation of the Alternative Complement Pathway in Macular Degeneration.
November 3, 2017In a study published online this week in the Human Molecular Genetics journal, Drs. Rosario Fernandez-Godino, Dr. Kinga M. Bujakowska, and Dr. Eric Pierce of the Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School reported the remarkable finding that the formation of basal deposits in macular degeneration is... Read More
New RO1 grant for Drs. Bujakowska and Pierce
November 3, 2017Drs. Bujakowska and Pierce are happy to have received a new RO1 grant for the project: Genetic Causes and Genetic Modifiers of Inherited Retinal Degenerations. Inherited retinal degenerations (IRDs) are a genetically heterogeneous group of disorders that are important causes of vision loss. The goals of the proposed research are to improve... Read More
Editas Medicine Initiates Clinical Natural History Study to Evaluate Patients with Leber Congenital Amaurosis Type 10 (LCA10)
September 21, 2017Massachusetts Eye and Ear named as first site for the study CAMBRIDGE, Mass., Sept. 12, 2017 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (NASDAQ:EDIT), a leading genome editing company, today announced that the Company initiated a clinical natural history study of Leber Congenital Amaurosis type 10 (LCA10). LCA10 is caused by mutations... Read More
RETINAL Transcriptome
June 3, 2017Original work (2013) View Data in Genome Browser PROJECT DETAILS The human retinal transcriptome data, available on the UCSC Genome Browser, was derived by performing RNA-Seq on 3 normal retina samples. Over 300 million 101 bp paired-end reads were aligned using the RNA-Seq Unified Mapper . These data are available as a... Read More
Young New Zealander Visits the OGI
May 1, 2017Louis Corbett, front left, learns the latest in eye research from Dr. Luk Vandenberghe. Louis Corbett, 12, is losing his vision due to Retinitis Pigmentosa, an inherited retinal degeneration that also affects his older brother. His parents decided to take him on a “bucket-list” tour so he could see the world before his vision is permanently... Read More
OGI Partners with Agilent
May 1, 2017MEEI Named by Agilent Technologies as Certified Service Provider for Next-Generation Sequencing and aCGH Solutions SANTA CLARA, Calif., Oct. 24, 2013 – Agilent Technologies Inc. (NYSE: A) today announced that the Massachusetts Eye and Ear Infirmary, an affiliate of Harvard Medical School,... Read More
OGI Fellow Wins Poster Award At ARVO
May 1, 2017OGI Fellow Wins MIT Poster Award Dr. Chari Fernadez Godino was awarded the 2014 MIT Outstanding Poster Award at this year's annual ARVO Meeting. Her winning poster was entitled "A Primary RPE cell culture model to study early mechanism of macular degeneration". Chari is senior fellow in the Pierce lab and her research is focused on... Read More
New Findings Published in BMC Genomics
May 1, 2017OGI Researcher Michael Farkas, Eric Pierce and colleagues publish groundbreaking findings in BMC Genomics; most thorough description of gene expression in the human retina to date. BOSTON (July 18, 2013) – Investigators at Massachusetts Eye and Ear and Harvard Medical School have published the most thorough description of gene expression... Read More
Harvard Medical School article featuring OGI researchers technique
May 1, 2017The Gene Therapy Renaissance: How one experimental technique overcame a troubled legacy and today is helping the blind to see R. ALAN LEO − April 18, 2013 In 1999, researchers at the University of Pennsylvania injected 19 people with a virus... Read More
GEDI Panel Released at MEEI
May 1, 2017The Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology today announced the availability of a comprehensive genetic diagnostic test for inherited retinal disease (IRD), early-onset glaucoma and optic atrophy. The Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology today announced the... Read More
GED-i Findings Published
May 1, 2017Mass. Eye and Ear Researchers Report that Panel-based Genetic Diagnostic Testing for Inherited Eye Diseases is Highly Accurate and More Sensitive than Exome Sequencing Findings published online in Genetics in Medicine BOSTON (November 20, 2014) Investigators at Massachusetts Eye and Ear and Harvard Medical School Department of... Read More